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J Org Chem. 2012 Sep 21;77(18):8000-6. Epub 2012 Sep 5.

Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.

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  • 1School of Biology, Aquatic Chemical Ecology Center, Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.


Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.

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