Send to:

Choose Destination
See comment in PubMed Commons below
Front Cell Infect Microbiol. 2012 Feb 20;2:15. doi: 10.3389/fcimb.2012.00015. eCollection 2012.

Defense and adaptation: the complex inter-relationship between Campylobacter jejuni and mucus.

Author information

  • 1Department of Biological Sciences, University of Alberta Edmonton, AB, Canada.


Mucus colonization is an essential early step toward establishing successful infection and disease by mucosal pathogens. There is an emerging literature implicating specific mucin sub-types and mucin modifications in protecting the host from Campylobacter jejuni infection. However, mucosal pathogens have evolved sophisticated mechanisms to breach the mucus layer and C. jejuni in particular appears to harbor specific adaptations to better colonize intestinal mucus. For example, components of mucus are chemotactic for C. jejuni and the rheological properties of mucus promote motility of the organism. Furthermore, recent studies demonstrate that mucins modulate the pathogenicity of C. jejuni in a species-specific manner and likely help determine whether these bacteria become pathogenic (as in humans), or adopt a commensal mode of existence (as in chickens and other animals). This review focuses on recent advances in understanding the complex interplay between C. jejuni and components of the mucus layer.


Campylobacter; chickens; motility; mucins; mucus; pathogenicity

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk