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J Med Microbiol. 2012 Dec;61(Pt 12):1746-9. doi: 10.1099/jmm.0.045229-0. Epub 2012 Aug 23.

Emergence of carbapenem-resistant OXA-48 carbapenemase-producing Enterobacteriaceae in Tunisia.

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  • 1Laboratoire de Bactériologie Virologie, Hôpital Charles Nicolle, Boulevard 9 Avril, 1006, Tunis, Tunisia.


We screened 21 extended spectrum β-lactamase-producing Enterobacteriaceae with reduced susceptibility to carbapenems for carbapenemase production. Five strains (four Klebsiella pneumoniae and one Citrobacter freundii) showed carbapenemase production, which was identified as OXA-48. The bla(OXA-48) gene was detected on ~54 kb plasmids belonging to IncA/C in one case. Two isolates harboured IS1999, which is involved in bla(OXA-48) mobilization. Carbapenem resistance in enterobacteria should be regarded as an emerging clinical problem in our hospital and necessitates rigorous surveillance in order to limit its spread.

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