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Neurology. 2012 Sep 4;79(10):1027-32. Epub 2012 Aug 22.

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.

Author information

  • 1Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.

Abstract

OBJECTIVE:

To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene.

METHODS:

In this observational study, 60 consecutive healthy first-degree relatives (aged 50.9 ± 6.2 years; 48% male; 30 G2019S carriers) were assessed using a computerized cognitive program, the Montreal Cognitive Assessment questionnaire, the Unified Parkinson's Disease Rating Scale Part III, and the Geriatric Depression Scale.

RESULTS:

G2019S carriers scored significantly lower on the computerized executive function index (p = 0.04) and on specific executive function tasks (Stroop test, p = 0.007).

CONCLUSION:

Carrying the LRRK2 G2019S mutation was associated with lower executive performance in a population at risk for PD.

PMID:
22914834
[PubMed - indexed for MEDLINE]
PMCID:
PMC3430708
Free PMC Article

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