Send to:

Choose Destination
See comment in PubMed Commons below
World J Biol Chem. 2012 Jun 26;3(6):110-20. doi: 10.4331/wjbc.v3.i6.110.

Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes.

Author information

  • 1Ly Q Hong-Brown, Abid A Kazi, Charles H Lang, Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, United States.


Alcoholism and acquired immune deficiency syndrome are associated with severe muscle wasting. This impairment in nitrogen balance arises from increased protein degradation and a decreased rate of protein synthesis. The regulation of protein synthesis is a complex process involving alterations in the phosphorylation state and protein-protein interaction of various components of the translation machinery and mammalian target of rapamycin (mTOR) complexes. This review describes mechanisms that regulate protein synthesis in cultured C2C12 myocytes following exposure to either alcohol or human immunodeficiency virus antiretroviral drugs. Particular attention is given to the upstream regulators of mTOR complexes and the downstream targets which play an important role in translation. Gaining a better understanding of these molecular mechanisms could have important implications for preventing changes in lean body mass in patients with catabolic conditions or illnesses.


AMP-activated protein kinase/tuberous sclerosis complex 2/Ras homolog enriched in brain; Elongation; Mitogen-activated protein kinase; Phospholipase D; Rag GTPases; Translation initiation

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk