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Nat Genet. 2012 Sep;44(9):978-80. doi: 10.1038/ng.2382. Epub 2012 Aug 19.

Mouse ooplasm confers context-specific reprogramming capacity.

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  • 1Broad Institute of MIT, Cambridge, Massachusetts, USA.

Abstract

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

PMID:
22902786
[PubMed - indexed for MEDLINE]
PMCID:
PMC3432711
Free PMC Article
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