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Hum Immunol. 2012 Nov;73(11):1082-6. doi: 10.1016/j.humimm.2012.07.328. Epub 2012 Aug 16.

Impact of infection or vaccination on pre-existing serological memory.

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  • 1Oregon National Primate Research Center, Oregon Health & Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

Abstract

Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3 years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.

Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

PMID:
22902392
[PubMed - indexed for MEDLINE]
PMCID:
PMC3478407
Free PMC Article

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