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Fertil Steril. 2012 Nov;98(5):1170-4. doi: 10.1016/j.fertnstert.2012.07.1108. Epub 2012 Aug 14.

Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism.

Author information

  • 1Department of Hematology and Transfusion Medicine, National Center of Hemostasis and Thrombosis, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.

Abstract

OBJECTIVE:

To evaluate the GP6 gene polymorphism in patients with sticky platelet syndrome (SPS) and fetal loss.

DESIGN:

Genetic association study.

SETTING:

Perinatal center.

PATIENT(S):

Twenty-seven patients with SPS, manifested as fetal loss, and 42 control subjects without SPS and no history of fetal loss and thrombosis.

INTERVENTION(S):

SPS was diagnosed by platelet aggregometry (PACKS-4 aggregometer; Helena Laboratories). Seven single-nucleotide polymorphisms (SNPs) of the GP6 gene were evaluated.

MAIN OUTCOME MEASURE(S):

Occurrence of SNPs of the GP6 gene in SPS patients versus control subjects.

RESULT(S):

We found a higher occurrence of three SNPs of the GP6 gene in SPS patients versus control subjects (rs1671153: 0.204 vs. 0.048, odds ratio [OR] 5.116, 95% confidence interval [CI] 1.536-17.03; rs1654419: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149-9.619; rs1613662: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149-9.619). The haplotype analysis showed a significantly higher occurrence of two haplotypes (CTGAG in haplotype 5: 0.185 vs. 0.059, OR 3.568, 95% CI 1.142-11.14; and CGATAG in haplotype 6: 0.204 vs. 0.048, OR 4.961, 95% CI 1.488-16.53).

CONCLUSION(S):

Our results, especially the higher occurrence of haplotypes CTGAG and CGATAG in SPS patients, support the idea that GP6 gene polymorphism may be associated with platelet hyperaggregability, a possible cause of fetal loss.

Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
22901851
[PubMed - indexed for MEDLINE]
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