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Nanoscale. 2012 Sep 28;4(19):5843-6. doi: 10.1039/c2nr31700a. Epub 2012 Aug 16.

Voltage controlled nano-injection system for single-cell surgery.

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  • 1Department of Biomolecular Engineering, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.


Manipulation and analysis of single cells is the next frontier in understanding processes that control the function and fate of cells. Herein we describe a single-cell injection platform based on nanopipettes. The system uses scanning microscopy techniques to detect cell surfaces, and voltage pulses to deliver molecules into individual cells. As a proof of concept, we injected adherent mammalian cells with fluorescent dyes.

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