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Dev Cell. 2012 Aug 14;23(2):329-41. doi: 10.1016/j.devcel.2012.05.022.

Kinocilia mediate mechanosensitivity in developing zebrafish hair cells.

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  • 1Howard Hughes Medical Institute, Oregon Hearing Research Center, 3181 SW Sam Jackson Park Road, Oregon Health and Science University, Portland, OR 97239, USA.

Abstract

Mechanosensitive cilia are vital to signaling and development across many species. In sensory hair cells, sound and movement are transduced by apical hair bundles. Each bundle is comprised of a single primary cilium (kinocilium) flanked by multiple rows of actin-filled projections (stereocilia). Extracellular tip links that interconnect stereocilia are thought to gate mechanosensitive channels. In contrast to stereocilia, kinocilia are not critical for hair-cell mechanotransduction. However, by sequentially imaging the structure of hair bundles and mechanosensitivity of individual lateral-line hair cells in vivo, we uncovered a central role for kinocilia in mechanosensation during development. Our data demonstrate that nascent hair cells require kinocilia and kinocilial links for mechanosensitivity. Although nascent hair bundles have correct planar polarity, the polarity of their responses to mechanical stimuli is initially reversed. Later in development, a switch to correctly polarized mechanosensitivity coincides with the formation of tip links and the onset of tip-link-dependent mechanotransduction.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22898777
[PubMed - indexed for MEDLINE]
PMCID:
PMC3426295
Free PMC Article

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