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Trans R Soc Trop Med Hyg. 2012 Oct;106(10):636-8. doi: 10.1016/j.trstmh.2012.07.010. Epub 2012 Aug 13.

Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.

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  • 1Sección Chagas, Servicio de Cardiología, Hospital Eva Perón, San Martín, Buenos Aires, Argentina.


In 12-18% of adult patients, treatment with benznidazole for chronic Chagas disease has to be discontinued because of side-effects. We identified and analysed a cohort of 81 adult patients with three positive tests for Trypanosoma cruzi infection and serological monitoring following incomplete treatment with benznidazole for a median of 10 days. Twenty percent of these patients (16/81) met the criteria of cure, showing that the optimal schedule of benznidazole administration remains to be determined.

Copyright © 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

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