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Cancer Cell. 2012 Aug 14;22(2):139-40. doi: 10.1016/j.ccr.2012.07.012.

Genomic analysis drives tailored therapy in poor risk childhood leukemia.

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  • 1Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.


Ph-like acute lymphoblastic leukemia (ALL) is a novel subgroup of high-risk childhood ALL. In this issue of Cancer Cell, Roberts et al. describe the identification of genetic alterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstrate that this aberrant signaling can be inhibited effectively.

Copyright © 2012 Elsevier Inc. All rights reserved.

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