Format

Send to:

Choose Destination
See comment in PubMed Commons below
Commun Integr Biol. 2012 May 1;5(3):243-7. doi: 10.4161/cib.19347.

An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins.

Abstract

Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs.

KEYWORDS:

PABP; PABPC1; PABPC4; RNA-binding protein; cellular stress response; nucleo-cytoplasmic transport; sub-cellular localization; translation initiation factor

PMID:
22896784
[PubMed]
PMCID:
PMC3419106
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk