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J Clin Microbiol. 2012 Nov;50(11):3726-8. doi: 10.1128/JCM.00620-12. Epub 2012 Aug 15.

Gene sequencing for routine verification of pyrazinamide resistance in Mycobacterium tuberculosis: a role for pncA but not rpsA.

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  • 1Public Health Ontario, Public Health Laboratories, Toronto, Ontario, Canada.

Abstract

Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis. Routine sequencing of pncA, but not rpsA, is effective for verification of PZA susceptibility results.

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PMID:
22895038
[PubMed - indexed for MEDLINE]
PMCID:
PMC3486241
Free PMC Article
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