[The effect of increased production of androgens on the development of body build morphology. Case report of an androgen-active tumor in a monozygotic twin]

Cesk Pediatr. 1990 Jul;45(7):408-10.
[Article in Czech]

Abstract

The authors present an account on monozygotic twins where in one girl an androgen-active adenoma of the adrenal cortex during early puberty led to the development of the Morphogram of Body Build (Case-report of throughout the period of investigation intact from the hormonal aspect. Four years after resection of the tumour endocrine and anthropometric characteristics of the two sisters were evaluated: the hormonal status of both is normal, the somatic differences are manifested by a different final height, biacromial width and chest circumference. The results are conceived as a precedent for evaluation of risks associated with administration of anabolic steroids in children.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications
  • Adenoma / genetics
  • Adenoma / metabolism*
  • Adrenal Cortex Neoplasms / complications
  • Adrenal Cortex Neoplasms / genetics
  • Adrenal Cortex Neoplasms / metabolism*
  • Androgens / metabolism*
  • Anthropometry
  • Body Constitution*
  • Child
  • Diseases in Twins*
  • Female
  • Humans
  • Virilism / etiology*
  • Virilism / pathology

Substances

  • Androgens