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Brain Res. 1990 Oct 29;531(1-2):342-5.

Is there a role for an endothelium-derived relaxing factor in nociception?

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  • 1Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.


Many of the circulating algesic agents released in response to ischemia produce a profound vasodilatation possibly through the release of an endothelium-derived relaxing factor (EDRF) as well as pain. We report here that intravenously administered S-nitrosocysteine, a putative EDRF, and not the nitric oxide liberating compound sodium nitroprusside produces significant alterations in nociceptive behavior that are abolished by bilateral vagotomy. These results are consistent with a role for EDRF in peripheral nociceptive mechanisms.

[PubMed - indexed for MEDLINE]
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