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Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9057-60. doi: 10.1002/anie.201202414. Epub 2012 Aug 13.

Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms.

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  • 1School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, New South Wales, Australia.

Abstract

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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