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Fertil Steril. 2012 Nov;98(5):1225-8. doi: 10.1016/j.fertnstert.2012.07.1056. Epub 2012 Aug 9.

Fertility preservation using controlled ovarian hyperstimulation and oocyte cryopreservation in a premenarcheal female with myelodysplastic syndrome.

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  • 1Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, New York, New York, USA.

Abstract

OBJECTIVE:

To report the first case of fertility preservation in a premenarcheal female by use of controlled ovarian hyperstimulation and oocyte cryopreservation.

DESIGN:

Case report.

SETTING:

Reproductive endocrinology and infertility unit of a tertiary care university-based medical center.

PATIENT(S):

A 13-year-old premenarcheal female with Tanner stage 3 breast development and Tanner stage 1 pubic hair diagnosed with myelodysplastic syndrome, referred by her medical oncologist for fertility preservation before undergoing a potentially sterilizing antineoplastic therapy.

INTERVENTION(S):

Evaluation of ovarian reserve, ovarian stimulation, transvaginal oocyte aspiration, in vitro maturation of immature oocytes, and oocyte cryopreservation.

MAIN OUTCOME MEASURE(S):

Cryopreservation of mature oocytes.

RESULT(S):

Successful controlled ovarian hyperstimulation allowed for the cryopreservation of 18 mature oocytes before the patient's gonadotoxic treatment. The oocyte retrieval and cryopreservation did not delay the patient's planned chemotherapy.

CONCLUSION(S):

Ovarian stimulation and oocyte cryopreservation can be successfully performed in premenarcheal/peripubertal patients, thus providing a viable alternative to ovarian tissue freezing for fertility preservation in the pediatric population.

Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
22884018
[PubMed - indexed for MEDLINE]
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