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Fertil Steril. 2012 Nov;98(5):1260-5.e1-2. doi: 10.1016/j.fertnstert.2012.07.1111. Epub 2012 Aug 9.

Tumor necrosis factor-alpha promoter polymorphisms are associated with idiopathic primary ovarian insufficiency in Korean women.

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  • 1Department of Obstetrics and Gynecology and Fertility Center of CHA Bundang Medical Center, CHA University, Seoul, South Korea.

Abstract

OBJECTIVE:

To investigate the possible association between primary ovarian insufficiency (POI) and TNF-α gene polymorphisms in Korean women.

DESIGN:

Case-control study.

SETTING:

An urban university-based hospital in South Korea.

PATIENT(S):

A cohort of 135 Korean POI patients and 236 controls.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

We analyzed TNF-α gene variants of all participants using the polymerase chain reaction-restriction fragment length polymorphism assay.

RESULT(S):

The TNF-α -1031TC+CC, -238GA+AA, -1031TC+CC/-308GG, -1031TT/-308GA+AA, -1031TC+CC/-238GA+AA, and -308GG/-238GA+AA genotypes were significantly more frequent in POI patients than in controls. Among the haplotypes for the three TNF-α loci, the -1031C/-308G/-238A haplotype was more frequent in POI patients than in controls and conferred POI susceptibility. In analyses of two loci, the -1031T/-308A, -1031C/-308G, -1031C/-238A, and -308G/-238A haplotypes were more frequent in POI patients.

CONCLUSION(S):

The TNF-α -1031C and -238A alleles had strong association with POI. The TNF-α -308A allele showed limited significance for POI risk with the presence of the -1031T allele. Our data suggest that the minor alleles of TNF-α promoter polymorphisms may increase POI risk in Korean women.

Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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