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Mol Cell. 2012 Aug 10;47(3):331-2. doi: 10.1016/j.molcel.2012.07.025.

Cullin RING ligases: glommed by glomulin.

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  • 1Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Abstract

Cullin ring ligases (CRLs) constitute the largest group of RING finger ubiquitin ligases. Two recent studies in Molecular Cell describe glomulin as a CRL1 inhibitor that blocks interactions with its ubiquitin-conjugating enzyme (E2) (Duda et al., 2012; Tron et al., 2012). These findings and their significance are discussed.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22883621
[PubMed]
PMCID:
PMC3448943
Free PMC Article
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