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Am J Addict. 2012 Sep-Oct;21(5):411-5. doi: 10.1111/j.1521-0391.2012.00253.x.

Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.

Author information

  • 1Center for Health, Quality, Outcomes & Economic Research, Edith Norse Rogers VA Medical Center, Bedford, Massachusetts, USA. david.smelson@va.gov

Abstract

BACKGROUND:

This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving.

METHODS:

Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive.

RESULTS:

Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03).

CONCLUSIONS:

These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.

Copyright © American Academy of Addiction Psychiatry.

PMID:
22882391
[PubMed - indexed for MEDLINE]
PMCID:
PMC3425941
Free PMC Article

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