Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br Med Bull. 2012 Sep;103(1):203-21. doi: 10.1093/bmb/lds022. Epub 2012 Aug 8.

The changing spectrum of rheumatic disease in HIV infection.

Author information

  • 1St. John's Way Medical Centre, London, UK.

Abstract

BACKGROUND:

Rheumatic manifestations were described soon after human immunodeficiency virus (HIV) was discovered. Since however, combination anti-retroviral therapy (cART) has revolutionized the course of the infection. Less clear is what effect cART has had on rheumatic manifestations.

SOURCES OF DATA:

References were retrieved from the PubMed database using keywords including: 'HIV' and 'arthritis'; 'myalgia'; 'arthralgia' and other disease-specific terms, e.g. 'rheumatoid arthritis'.

AREAS OF AGREEMENT:

Musculoskeletal pain was common in HIV and increased with AIDS. Immune restoration inflammatory syndrome on initiation of cART causes de novo autoimmune inflammatory rheumatic disorders. Seronegative inflammatory arthritis with/without axial involvement has been reported widely with HIV.

AREAS OF CONTROVERSY:

It is unclear if HIV causes these conditions, creates an environmental milieu supportive of these conditions or acts as a marker of other risk factors. It is unclear what effect cART has had on these conditions.

GROWING POINTS:

Variable diagnostic classification criteria have caused this literature to be poorly comparable.

AREAS TIMELY FOR DEVELOPING RESEARCH:

High-quality controlled epidemiological studies using standardized criteria are needed among cART users. Treatment of active autoimmune disease in HIV patients needs to be evaluated formally.

PMID:
22879627
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk