Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Prog Brain Res. 2012;199:337-58. doi: 10.1016/B978-0-444-59427-3.00019-8.

The impact of the circadian timing system on cardiovascular and metabolic function.

Author information

  • 1Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, USA. cjmorris@rics.bwh.harvard.edu

Abstract

Epidemiological studies show that adverse cardiovascular events peak in the morning (i.e., between 6 AM and noon) and that shift work is associated with cardiovascular disease, obesity, and diabetes. The endogenous circadian timing system modulates certain cardiovascular risk markers to be highest (e.g., cortisol, nonlinear dynamic heart rate control, and platelet activation) or to respond most unfavorably to stressors such as exercise (e.g., epinephrine, norepinephrine, and vagal cardiac modulation) at an internal body time corresponding to the time of day when adverse cardiovascular events most likely occur. This indicates that the circadian timing system and its interaction with external cardiovascular stressors (e.g., physical activity) could contribute to the morning peak in adverse cardiovascular events. Moreover, circadian misalignment and simulated night work have adverse effects on cardiovascular and metabolic function. This suggests that misalignment between the behavioral cycle and the circadian timing system in shift workers contributes to that population's increased risk for cardiometabolic disease.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22877674
[PubMed - indexed for MEDLINE]
PMCID:
PMC3704149
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk