Porphyrin-lipid stabilized gold nanoparticles for surface enhanced Raman scattering based imaging

Bioconjug Chem. 2012 Sep 19;23(9):1726-30. doi: 10.1021/bc300214z. Epub 2012 Aug 16.

Abstract

A porphyrin-phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal microscopy, we show that this porphyrin-lipid stabilized AuNP is a novel SERS probe capable of cellular imaging. To date, this is the first use of porphyrin as a Raman reporter molecule for SERS based imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Biocompatible Materials
  • Gold / chemistry*
  • Lipids / chemistry*
  • Metal Nanoparticles*
  • Microscopy, Confocal
  • Porphyrins / chemistry*
  • Spectrum Analysis, Raman / methods*

Substances

  • Biocompatible Materials
  • Lipids
  • Porphyrins
  • Gold