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Acta Pol Pharm. 2012 Jul-Aug;69(4):669-77.

Anticancer activity of new (tetrazol-5-yl)methylindole derivatives and their acyclic c-nucleoside analogs.

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  • 1Department of Photochemistry, National Research Centre, Cairo, Egypt. adelnassar63@hotmail.com

Abstract

New (tetrazol-5-yl)methylindole derivatives were synthesized from 2-phenylindole. Furthermore, the sugar acetyl hydrazones of the tetrazole derivatives as well as their derived acyclic C-nucleoside analogs were prepared. The synthesized compounds were studied for their anticancer activity against human liver carcinoma cell line (HepG2) and the results showed that arylidine substituted tetrazole derivatives 7c and 7d were the most active.

PMID:
22876609
[PubMed - indexed for MEDLINE]
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