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J Pediatr Endocrinol Metab. 2012;25(5-6):467-70.

Vitamin D status in children with Hashimoto thyroiditis.

Author information

  • 1Department of Pediatric Endocrinology, School of Medicine, Gazi University, Ankara, Turkey. turkalpo@yahoo.com

Abstract

OBJECTIVE:

To investigate vitamin D status in children with Hashimoto thyroiditis.

SUBJECTS AND METHODS:

The study group consisted of 78 children recently diagnosed as Hashimoto thyroiditis and 74 subjects as the control group. Parameters of calcium metabolism, thyroid function tests, and 25-hydroxyvitamin D [25(OH)D] levels were measured.

RESULTS:

Vitamin D deficiency rate was significantly higher in the Hashimoto group compared with the control subjects (73.1% vs. 17.6%, p < 0.0001). In the Hashimoto group, mean 25(OH)D levels were significantly lower compared with the control group (31.2 +/- 11.5 versus 57.9 +/- 19.7 nmol/L, p < 0.001) and was inversely correlated with the anti-thyroid peroxidase (anti-TPO) levels (r = -0.30, p = 0.007).

CONCLUSION:

The higher vitamin D deficiency rates besides lower vitamin D levels in the Hashimoto group together with the inverse correlation between vitamin D and anti-TPO suggest that vitamin D deficiency may have a role in the autoimmune process in Hashimoto thyroiditis in children.

PMID:
22876540
[PubMed - indexed for MEDLINE]
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