Display Settings:

Format

Send to:

Choose Destination
Front Oncol. 2012 Aug 2;2:87. doi: 10.3389/fonc.2012.00087. eCollection 2012.

Endoplasmic reticulum involvement in yeast cell death.

Author information

  • Department of Biology, Providence College, Providence, RI, USA.

Abstract

Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of N-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death.

KEYWORDS:

BXI1; ER stress; IRE1; UPR; endoplasmic reticulum; yeast cell death

PMID:
22876361
[PubMed]
PMCID:
PMC3410633
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk