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Diabetes Care. 2012 Nov;35(11):2390-2. doi: 10.2337/dc12-0464. Epub 2012 Aug 8.

Progression of vascular calcification is increased with statin use in the Veterans Affairs Diabetes Trial (VADT).

Author information

  • 1Phoenix VA Health Care System, Phoenix, AZ, USA. aramesh.saremi@va.gov

Abstract

OBJECTIVE:

To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM).

RESEARCH DESIGN AND METHODS:

Progression of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) was assessed according to the frequency of statin use in 197 participants with T2DM.

RESULTS:

After adjustment for baseline CAC and other confounders, progression of CAC was significantly higher in more frequent statin users than in less frequent users (mean ± SE, 8.2 ± 0.5 mm(3) vs. 4.2 ± 1.1 mm(3); P < 0.01). AAC progression was in general not significantly increased with more frequent statin use; in a subgroup of participants initially not receiving statins, however, progression of both CAC and AAC was significantly increased in frequent statin users.

CONCLUSIONS:

More frequent statin use is associated with accelerated CAC in T2DM patients with advanced atherosclerosis.

PMID:
22875226
[PubMed - indexed for MEDLINE]
PMCID:
PMC3476911
Free PMC Article

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