Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Gastroenterol Belg. 2012 Jun;75(2):210-4.

Molecular changes in pancreatic cancer: implications for molecular targeting therapy.

Author information

  • 1Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium. pieter.demetter@erasme.ulb.ac.be

Abstract

Pancreatic ductal adenocarcinoma has a high mortality rate, which is generally related to the initial diagnosis coming at late stage disease combined with a lack of effective treatment options. Gemcitabine has been the most commonly used drug over the past decade and is still the cornerstone of therapy in adjuvant and metastatic settings. Intrinsic or acquired resistance of tumours to gemcitabine is, however, a major clinical problem. New therapeutic strategies are urgently needed whereas we also need to identify new prognostic and predictive biomarkers. This article focuses on gemcitabine resistance, on the role of chemokines and chemokine receptors in pancreatic carcinoma initiation and progression, and on stellate cells as partners in crime with neoplastic epithelial cells.

PMID:
22870784
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk