Send to:

Choose Destination
See comment in PubMed Commons below
Clin Cancer Res. 2012 Sep 15;18(18):4865-7. doi: 10.1158/1078-0432.CCR-12-2090. Epub 2012 Aug 6.

Hidden dangers: a cryptic exon disrupts BRCA2 mRNA.

Author information

  • 1Center for Clinical Cancer Genetics and Global Health, The University of Chicago Medical Center, Chicago, IL 60637, USA.


The first mutation that disrupts BRCA2 mRNA by including a novel, cryptic exon is reported in this issue. The mutation lies deep within an intron and would not have been detected by conventional screening methods. In the future, more mutations may be discovered by direct mRNA analysis.

©2012 AACR.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk