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Appl Radiat Isot. 2012 Oct;70(10):2298-307. doi: 10.1016/j.apradiso.2012.06.005. Epub 2012 Jun 26.

Synthesis and comparison of 4-[18F]F-ADAM, 2-[18F]F-ADAM, N-Desmethyl-4-[18F]F-ADAM and [18F]F-AFM as serotonin transporter imaging agents.

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  • 1PET Center, Department of Nuclear Medicine, Tri-Service General Hospital, Neihu 114, Taipei, Taiwan.

Abstract

4-[(18)F]F-ADAM (1a), 2-[(18)F]F-ADAM (2a), N-Desmethyl-4-[(18)F]F-ADAM (3a) and [(18)F]F-AFM (4a ) were synthesized in 1.7, 3.9, 2.9 and 0.6% yield (EOS), respectively, in a synthesis time of ~120 min from EOB. PET studies in rats showed that the maximum specific uptake ratios of 1a, 2a, 3a and 4a in midbrain were 3.86, 0.73, 0.35 and 2.23, respectively. Thus, in terms of radiochemical yield, specific binding and in vivo stability, 4-[(18)F]F-ADAM may be the most appropriate SERT imaging agent for human studies.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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