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ACS Chem Neurosci. 2012 Apr 18;3(4):319-24. doi: 10.1021/cn3000058. Epub 2012 Feb 17.

BODIPY-based molecular probe for imaging of cerebral β-amyloid plaques.

Author information

  • 1Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University , 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. ono@pharm.kyoto-u.ac.jp

Abstract

We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic Aβ aggregates. β-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of β-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral β-amyloid plaques in patients with Alzheimer's disease.

KEYWORDS:

Alzheimer’s disease; BODIPY; optical imaging; β-amyloid plaque

PMID:
22860198
[PubMed - indexed for MEDLINE]
PMCID:
PMC3369805
Free PMC Article
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