Send to

Choose Destination
See comment in PubMed Commons below
Jpn J Ophthalmol. 2012 Sep;56(5):511-4. doi: 10.1007/s10384-012-0170-3. Epub 2012 Jul 27.

Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease.

Author information

  • 1Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, Kagawa 769-1695, Japan.



We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.


An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.


IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk