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Jpn J Ophthalmol. 2012 Sep;56(5):511-4. doi: 10.1007/s10384-012-0170-3. Epub 2012 Jul 27.

Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease.

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  • 1Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, Kagawa 769-1695, Japan. rivon-sogabe@k9.dion.ne.jp

Abstract

PURPOSE:

We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.

CASE:

An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.

CONCLUSION:

IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.

[PubMed - indexed for MEDLINE]
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