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Mar Drugs. 2012 Jul;10(7):1536-44. doi: 10.3390/md10071536. Epub 2012 Jul 19.

4-Methylenesterols from a sponge Theonella swinhoei.

Author information

  • 1National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. idun031177@hotmail.com

Abstract

Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.

KEYWORDS:

4-methylenesterols; Theonella; sponge

PMID:
22851924
[PubMed - indexed for MEDLINE]
PMCID:
PMC3407929
Free PMC Article

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