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J Clin Invest. 2012 Aug 1;122(8):2722-3. doi: 10.1172/JCI65404. Epub 2012 Aug 1.

Take a deep breath: pulmonary research inspires.

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  • Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. paul.noble@duke.edu


The lung is a complex organ with multiple functions; in addition to facilitating gas exchange, it also serves as the first line of defense against inhaled environmental pathogens and toxins. Given these critical roles, disruption of normal cell function or cell-cell interactions can have devastating health consequences. The articles of this Review Series highlight recent progress in understanding the pathophysiology of several pulmonary diseases and suggest how these insights are leading to the development of new therapeutic strategies.

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