The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats

Reprod Biol. 2012 Jul;12(2):247-55. doi: 10.1016/s1642-431x(12)60089-8.

Abstract

The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited persistent diestrous as well as ovaries containing cystic follicles. Upon treatment with TAF 273, fewer animals showed irregular estrous cycles and there was less follicular morphological damage. The reversal effect may be derived from the anti-estrogenic properties of the plant quassinoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amenorrhea / chemically induced
  • Amenorrhea / drug therapy*
  • Analysis of Variance
  • Animals
  • Eurycoma / chemistry*
  • Female
  • Phytotherapy / methods*
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry
  • Polycystic Ovary Syndrome / chemically induced
  • Polycystic Ovary Syndrome / drug therapy*
  • Quassins / pharmacology*
  • Quassins / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Testosterone / toxicity*
  • Treatment Outcome

Substances

  • Plant Extracts
  • Quassins
  • Testosterone