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C R Biol. 2012 Jul;335(7):454-62. doi: 10.1016/j.crvi.2012.05.005. Epub 2012 Jun 29.

Adult hematopoietic progenitors are multipotent in chimeric mice.

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  • 1CNRS UMR, Université Paris Descartes, France. bernard.pessac@wanadoo.fr


Embryonic stem cells (ESCs) and adult somatic cells, induced to pluripotency (iPSCs), can differentiate into multiple cell lineages. We previously reported that adult mammalian bone marrow contains a sub-population of CD34+ cells that express genes of ESCs and genes required to generate iPSCs. They also express lineage genes of the three embryonic germ layers. Are these CD34+ cells multipotent? Here, CD34+ bone marrow stem cells from adult male ROSA mice, which carry two markers: the β-galactosidase gene and the male Y chromosome, were transplanted into blastocysts of wildtype mice. Each female ROSA chimera generated had a distinct pattern of male-derived organs expressing β-galactosidase; e.g., ectodermal brain, dorsal root ganglia and skin; mesodermal heart, bone and bone marrow; and endodermal pancreas, intestine, and liver. Thus, adult mammals carry cells that appear to exhibit a developmental potential reminiscent of ESCs and iPSCs suggesting they could be used for cell replacement therapy.

Copyright © 2012 Académie des sciences. Published by Elsevier SAS. All rights reserved.

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