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Curr Opin Virol. 2012 Oct;2(5):572-9. doi: 10.1016/j.coviro.2012.07.004. Epub 2012 Jul 28.

Human viral diseases: what is next for antiviral drug discovery?

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  • 1Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.


For the treatment of human immunodeficiency virus (HIV) infections for which there are ample drugs available, the immediate future lies in a once-daily combination pill containing three or four active ingredients. This strategy may also be envisaged for the treatment of hepatitis C virus (HCV) infections as soon as we have at hand the appropriate direct-acting antiviral agents (DAAs) to be combined. A combination drug therapy is generally not entertained for other viruses. Yet, new drugs are at the horizon for the treatment of herpes simplex virus (HSV), varicella-zoster virus (VZV), poxvirus, hepatitis B virus (HBV), influenza and enveloped viruses-at-large.

Copyright © 2012 Elsevier B.V. All rights reserved.

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