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Allergy. 2012 Oct;67(10):1316-8. doi: 10.1111/j.1398-9995.2012.02877.x.. Epub 2012 Jul 30.

Co-factor-enhanced food allergy.

Author information

  • 1Allergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain. vcardona@vhebron.net

Abstract

BACKGROUND:

Alcohol, exercise or non-steroidal anti-inflamatory drugs (NSAID) are frequently mentioned as amplifiers of food allergic reactions but only individual cases or small series have been previously published.

METHODS:

Descriptive study including 74 cases of suspected co-factor enhanced food allergy, assessed by skin-prick tests, specific IgE and oral challenges.

RESULTS:

Anaphylaxis accounted for 85.1% of reactions. In 99% of cases culprit food allergens were plant-derived, mainly vegetables and cereals. NSAID were involved in 58%, exercise in 52.7% and alcohol in 12.2%. Lipid transfer protein was the most frequently involved allergen.

CONCLUSIONS:

Co-factor enhanced food allergy should be considered when assessing food, alcohol, exercise and NSAID allergic reactions.

© 2012 John Wiley & Sons A/S.

PMID:
22845005
[PubMed - indexed for MEDLINE]
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