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PLoS Genet. 2012;8(7):e1002854. doi: 10.1371/journal.pgen.1002854. Epub 2012 Jul 26.

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

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  • 1Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.


We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

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