Abstract
Presence of symptomatic patent ductus arteriosus is common in small preterm infants and ibuprofen is commonly used for its medical closure. While efficacy is comparable to indomethacin, there are few case reports of severe hypoxemia and pulmonary hypertension following prophylactic ibuprofen administration. Cumulative dose effects and chemical composition may be important considerations. Possible mechanisms of occurrence of this complication in a preterm infant are discussed.
MeSH terms
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Cyclooxygenase Inhibitors / administration & dosage
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Cyclooxygenase Inhibitors / adverse effects
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Ductus Arteriosus, Patent / drug therapy*
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Humans
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Hypertension, Pulmonary / chemically induced*
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Ibuprofen / administration & dosage
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Ibuprofen / adverse effects
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Ibuprofen / analogs & derivatives*
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Infant, Premature
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Infant, Premature, Diseases / drug therapy*
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Infant, Very Low Birth Weight
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Lysine / administration & dosage
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Lysine / adverse effects
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Lysine / analogs & derivatives*
Substances
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Cyclooxygenase Inhibitors
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Lysine
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solufenum
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Ibuprofen