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Eur J Vasc Endovasc Surg. 2012 Sep;44(3):301-6. doi: 10.1016/j.ejvs.2012.06.017. Epub 2012 Jul 25.

Vitamin D deficiency may be an independent risk factor for arterial disease.

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  • 1Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Abstract

OBJECTIVES:

The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease.

METHODS:

We included 490 patients with symptomatic peripheral arterial disease (PAD, n = 254) or aortic aneurysm (n = 236). Cardiovascular risk factors and comorbidities carotid intima-media thickness (CIMT), ankle-brachial index (ABI), serum high-sensitive C-reactive protein (hs-CRP) and vitamin D were assessed. Patients were categorised into severely (≤25 nmol l(-1)) or moderately (26-50 nmol l(-1)) vitamin D deficient, vitamin D insufficient (51-75 nmol l(-1)) or vitamin D sufficient (>75 nmol l(-1)).

RESULTS:

Overall, 45% of patients suffered from moderate or severe vitamin D deficiency. The prevalence of vitamin D deficiency was similar in patients with PAD and those with an aortic aneurysm. Low levels of vitamin D were associated with congestive heart failure and cerebrovascular disease. Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT (P = 0.001), lower ABI (P < 0.001) and higher hs-CRP (P = 0.022).

CONCLUSIONS:

The current study shows a strong association between low vitamin D status and arterial disease, independent of traditional cardiovascular risk factors and irrespective of the type of vascular disease, that is, occlusive or aneurysmatic disease.

Copyright © 2012. Published by Elsevier Ltd.

PMID:
22841360
[PubMed - indexed for MEDLINE]
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