Mol Cell. 2012 Jul 27;47(2):153-5. doi: 10.1016/j.molcel.2012.07.007.

Should I stay or should I go? Chromodomain proteins seal the fate of heterochromatic transcripts in fission yeast.

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Department of Biochemistry, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

Abstract

In this issue of Molecular Cell, Ishida et al. (2012) and Keller et al. (2012) show distinct outcomes for heterochromatic RNAs that bind different chromodomain proteins; Chp1 tethers transcripts to centromeres, whereas Swi6(HP1)-bound transcripts are evicted from chromatin and destroyed.

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HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. [Mol Cell. 2012]
HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts.Keller C, Adaixo R, Stunnenberg R, Woolcock KJ, Hiller S, Bühler M. Mol Cell. 2012 Jul 27; 47(2):215-27. Epub 2012 Jun 7.
Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing. [Mol Cell. 2012]
Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing.Ishida M, Shimojo H, Hayashi A, Kawaguchi R, Ohtani Y, Uegaki K, Nishimura Y, Nakayama J. Mol Cell. 2012 Jul 27; 47(2):228-41. Epub 2012 Jun 21.

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Should I stay or should I go? Chromodomain proteins seal the fate of heterochrom...
Should I stay or should I go? Chromodomain proteins seal the fate of heterochromatic transcripts in fission yeast.
Mol Cell. 2012 Jul 27 ;47(2):153-5. doi: 10.1016/j.molcel.2012.07.007.

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Should I stay or should I go? Chromodomain proteins seal the fate of heterochromatic transcripts in fission yeast.

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