Display Settings:


Send to:

Choose Destination
J Affect Disord. 2013 Feb 20;145(2):264-9. doi: 10.1016/j.jad.2012.05.062. Epub 2012 Jul 25.

Neurocognitive alterations in first degree relatives of suicide completers.

Author information

  • 1McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Blvd., Montreal, QC, Canada H4H 1R3. alexander.mcgirr@alum.utoronto.ca



Suicide aggregates within families and the relatives of suicide completers are at an increased risk for suicide. Though neurocognitive changes are gaining increasing attention as part of the vulnerability for suicide, the literature on neurocognitive alterations among suicide relatives as possible endophenotypes of suicide is sparse.


Normothymic first-degree relatives (n=14) of suicide completers without personal histories of suicide attempts were compared to individuals without family histories of suicide (n=14) matched for age-, sex- and education. Participants completed the Wisconsin card sorting test, a well validated test of cognitive control in a changing environment.


First-degree relatives of suicide completers made significantly more perseverative errors and have a lower level of conceptual responses than comparison subjects.


Alterations found in first-degree relatives of suicide completers suggest a decreased responsiveness to changing, yet unambiguous, conditions. These neurocognitive impairments are similar to deficits observed among individuals engaging in suicide attempts. Neurocognitive impairments revealed by the Wisconsin card sorting test may represent a neurocognitive endophenotype of suicide.

Copyright © 2012 Elsevier B.V. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk