Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Rep. 2012 Jul 26;2(1):33-41. doi: 10.1016/j.celrep.2012.05.011. Epub 2012 Jul 11.

Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing.

Author information

  • 1Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic activation achieved via in vitro optogenetic stimulation of nucleus accumbens, a terminal field of dopaminergic neurons, elicits real-time dopamine release. This mechanism occurs via direct actions on dopamine terminals, does not require changes in neuron firing within the midbrain, and is dependent on glutamatergic receptor activity. More importantly, we demonstrate that in vivo selective activation of cholinergic interneurons is sufficient to elicit dopamine release in the nucleus accumbens. Therefore, the control of accumbal extracellular dopamine levels by endogenous cholinergic activity results from a complex convergence of neurotransmitter/neuromodulator systems that may ultimately synergize to drive motivated behavior.

Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.

PMID:
22840394
[PubMed - indexed for MEDLINE]
PMCID:
PMC3408582
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk