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    Diabetes Care. 2012 Nov;35(11):2300-2. doi: 10.2337/dc12-0205. Epub 2012 Jul 26.

    Cyclical variation in the incidence of childhood type 1 diabetes in Western Australia (1985-2010).

    Source

    Department of Endocrinology and Diabetes, Princess Margaret Hospital, Perth, Western Australia, Australia.

    Abstract

    OBJECTIVE:

    To examine the incidence of childhood type 1 diabetes in Western Australia from 1985-2010.

    RESEARCH DESIGN AND METHODS:

    Incidence rates were calculated for children aged 0-14 years and were analyzed by calendar year, sex, and age at diagnosis.

    RESULTS:

    There were 1,873 cases, and the mean incidence was 18.1/100,000 person-years (95% CI: 17.5-19.2). The incidence increased by 2.3% a year (1.6-2.9%) with a sinusoidal 5-year cyclical variation of 14% (7-22%). The lowest rate of increase in incidence was observed in 0-4-year-olds.

    CONCLUSIONS:

    The cyclical pattern in incidence observed supports the role of environmental factors in childhood type 1 diabetes.

    PMID:
    22837374
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3476891
    [Available on 2013/11/1]

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