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Diabetes Care. 2012 Nov;35(11):2300-2. doi: 10.2337/dc12-0205. Epub 2012 Jul 26.

Cyclical variation in the incidence of childhood type 1 diabetes in Western Australia (1985-2010).

Author information

  • 1Department of Endocrinology and Diabetes, Princess Margaret Hospital, Perth, Western Australia, Australia.

Abstract

OBJECTIVE:

To examine the incidence of childhood type 1 diabetes in Western Australia from 1985-2010.

RESEARCH DESIGN AND METHODS:

Incidence rates were calculated for children aged 0-14 years and were analyzed by calendar year, sex, and age at diagnosis.

RESULTS:

There were 1,873 cases, and the mean incidence was 18.1/100,000 person-years (95% CI: 17.5-19.2). The incidence increased by 2.3% a year (1.6-2.9%) with a sinusoidal 5-year cyclical variation of 14% (7-22%). The lowest rate of increase in incidence was observed in 0-4-year-olds.

CONCLUSIONS:

The cyclical pattern in incidence observed supports the role of environmental factors in childhood type 1 diabetes.

PMID:
22837374
[PubMed - indexed for MEDLINE]
PMCID:
PMC3476891
Free PMC Article

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