Format

Send to:

Choose Destination
See comment in PubMed Commons below
Transl Psychiatry. 2011 Jul 19;1:e21. doi: 10.1038/tp.2011.21.

Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor.

Author information

  • 1Department of Psychology, University of Konstanz and Center for Psychiatry Reichenau, Konstanz, Germany.

Abstract

Prenatal exposure to maternal stress can have lifelong implications for psychological function, such as behavioral problems and even the development of mental illness. Previous research suggests that this is due to transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis, such as the glucocorticoid receptor (GR). However, it is not known whether intrauterine exposure to maternal stress affects the epigenetic state of these genes beyond infancy. Here, we analyze the methylation status of the GR gene in mothers and their children, at 10-19 years after birth. We combine these data with a retrospective evaluation of maternal exposure to intimate partner violence (IPV). Methylation of the mother's GR gene was not affected by IPV. For the first time, we show that methylation status of the GR gene of adolescent children is influenced by their mother's experience of IPV during pregnancy. As these sustained epigenetic modifications are established in utero, we consider this to be a plausible mechanism by which prenatal stress may program adult psychosocial function.

PMID:
22832523
[PubMed - indexed for MEDLINE]
PMCID:
PMC3309516
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk