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Nanomedicine (Lond). 2012 Nov;7(11):1697-711. doi: 10.2217/nnm.12.65. Epub 2012 Jul 26.

Preliminary study of injury from heating systemically delivered, nontargeted dextran-superparamagnetic iron oxide nanoparticles in mice.

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  • 1Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB I, Baltimore, MD 21231, USA.

Abstract

AIM:

To assess the potential for injury to normal tissues in mice due to heating systemically delivered magnetic nanoparticles in an alternating magnetic field (AMF).

MATERIALS & METHODS:

Twenty three male nude mice received intravenous injections of dextran-superparamagnetic iron oxide nanoparticles on days 1-3. On day 6, they were exposed to AMF. On day 7, blood, liver and spleen were harvested and analyzed.

RESULTS:

Iron deposits were detected in the liver and spleen. Mice that had received a high-particle dose and a high AMF experienced increased mortality, elevated liver enzymes and significant liver and spleen necrosis. Mice treated with low-dose superparamagnetic iron oxide nanoparticles and a low AMF survived, but had elevated enzyme levels and local necrosis in the spleen.

CONCLUSION:

Magnetic nanoparticles producing only modest heat output can cause damage, and even death, when sequestered in sufficient concentrations. Dextran-superparamagnetic iron oxide nanoparticles are deposited in the liver and spleen, making these the sites of potential toxicity. Original submitted 16 August 2011; Revised submitted 21 March 2012; Published online 26 July 2012.

PMID:
22830502
[PubMed - indexed for MEDLINE]
PMCID:
PMC3991127
Free PMC Article
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