Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Org Lett. 2012 Aug 3;14(15):3912-5. doi: 10.1021/ol301660f. Epub 2012 Jul 24.

Gold-catalyzed hydrosilyloxylation driving tandem aldol and Mannich reactions.

Author information

  • 1Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea.

Abstract

The chemoselective formation of an enolate from alkyne in the presence of a carbonyl and imine group was realized, which constructed a variety of structural motifs under exceedingly mild reaction conditions in a tandem process. Reaction driving tandem hydrosilyloxylation/aldol reactions was achieved through the formation of enol silyl ethers catalytically generated in situ from readily available alkynes. These reactions were expanded to obtain β-amino enol silyl ethers in good yields via the tandem hydrosilyloxylation/isomerization/Mannich reaction.

PMID:
22827547
[PubMed]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk