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Clin Exp Gastroenterol. 2012;5:113-21. doi: 10.2147/CEG.S32368. Epub 2012 Jul 5.

Lactose intolerance: diagnosis, genetic, and clinical factors.

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  • 1Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.

Abstract

Most people are born with the ability to digest lactose, the major carbohydrate in milk and the main source of nutrition until weaning. Approximately 75% of the world's population loses this ability at some point, while others can digest lactose into adulthood. This review discusses the lactase-persistence alleles that have arisen in different populations around the world, diagnosis of lactose intolerance, and its symptomatology and management.

KEYWORDS:

LCT gene; MCM6 gene; hypolactasia; lactase non-persistence; lactase persistence; lactose

PMID:
22826639
[PubMed]
PMCID:
PMC3401057
Free PMC Article
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